Changfu® C1811: The Key Precursor for High-Performance C18 Columns.

     ChangFu^® C1811 (n-Octadecyldimethylchlorosilane; CAS: 18643-08-8) is a critical surface modifier for the preparation of reversed-phase HPLC columns. Utilizing advanced surface bonding technology, it constructs a non-polar hydrophobic layer with high carbon content and exceptional stability on the silica gel matrix. This unique bonded structure significantly enhances the column's tolerance for complex biological macromolecules while ensuring superior separation performance.

1.  Mechanism of Action

• Strong Hydrophobicity & High Reactivity

The long C18 alkyl chain provides strong hydrophobicity, while the highly reactive chlorine functional groups form stable structures via covalent bonds. This chemical bonding method is robust and reliable, preventing stationary phase loss during operation and significantly improving column stability.

• Stationary Phase Construction

Changfu^® C1811 forms a uniform and dense non-polar hydrophobic layer on the silica surface. The resulting bonded structure combines the rigidity of the silica matrix with the stability of the organic ligand, ensuring consistent performance within standard operating ranges and compatibility with most analytical scenarios.

• Separation Mechanism

When a polar solvent is used as the mobile phase, polar components interact more readily with the mobile phase and are eluted quickly. Conversely, non-polar components exhibit strong interactions with the C18 hydrophobic layer, resulting in longer retention times.

2.  Performance Advantages

• High Carbon Loading: The hydrophobic layer design enhances retention capabilities for complex biological macromolecules.
• Structural Stability: The stable covalent bonding structure reduces the risk of irreversible adsorption.
• High-Resolution Separation: Enables efficient separation of components with similar polarity and structure by leveraging precise differences in hydrophobic interactions.
• Anti-Contamination: Possesses strong resistance to contamination, ensuring stable analytical results for complex samples.

With its high carbon loading and strong covalent bonding, ChangFu^® C1811 endows HPLC columns with excellent hydrophobic selectivity and anti-contamination capabilities. It is the ideal choice for improving chromatographic efficiency and extending column lifespan.

For more product information and applications, please contact us:

Mobile: (+86) 181-6277-0058

Email: sales@cfsilanes.com

Key words: n-Octadecyldimethylchlorosilane; CAS: 18643-08-8; HPLC columns; C18 Columns; Hydrophobicity.